Elastin-like polypeptides: protein-based polymers for biopharmaceutical development
نویسندگان
چکیده
منابع مشابه
Elastin-like polypeptides as a promising family of genetically-engineered protein based polymers
Elastin-like polypeptides (ELP) are artificial, genetically encodable biopolymers, belonging to elastomeric proteins, which are widespread in a wide range of living organisms. They are composed of a repeating pentapeptide sequence Val-Pro-Gly-Xaa-Gly, where the guest residue (Xaa) can be any naturally occurring amino acid except proline. These polymers undergo reversible phase transition that c...
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Aqueous solutions of commercial poly(oxyethylene) – poly(oxypropylene) – poly(oxyethylene), triblock co-polymers (PEOx – PPOy – PEOx, Pluronics©) undergo both micellization and structural arrangement as a function of increasing temperature. In the case of Pluronic F127 (PEO100 – PPO65 – PEO100), this structural arrangement is observed macroscopically as a liquid to gel transition for polymer co...
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Silk-elastin-like protein polymers (SELPs) combine the mechanical and biological properties of silk and elastin. These properties have led to the development of various SELP-based materials for drug delivery. However, SELPs have rarely been developed into nanoparticles, partially due to the complicated fabrication procedures, nor assessed for potential as an anticancer drug delivery system. We ...
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BACKGROUND Safe and effective hemostatic materials are important for reducing mortality resulting from excessive hemorrhage. In this work, new biomaterials with hemostatic effects were created by fusing the gene coding for RADA-16, a self-assembling peptide with the sequence RADARADARADARADA, to the 3'-end of the open reading frame (ORF) encoding elastin-like polypeptides through gene recombina...
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In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function. Therefore, in lieu of using natural components, we created biomimetic matrices using geneticall...
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ژورنال
عنوان ژورنال: Chimia
سال: 2022
ISSN: ['0009-4293', '2673-2424']
DOI: https://doi.org/10.2533/chimia.2022.478